Web12 de set. de 2024 · Hypoxia inducible factor (HIF) and mammalian target of rapamycin (mTOR) pathways orchestrate responses to oxygen and nutrient availability. These pathways are frequently dysregulated in cancer ... Web9 de jul. de 2015 · To prove if Akt/mTOR/HIF-1α axis is involved in elevated aerobic glycolysis in tamoxifen-resistant breast cancer cells, their phosphorylation status or expression levels were investigated by western blot analysis after knockdown of HK-2 or 3-BrPA treatment followed by 4-OHT treatment in three cell lines.
Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis …
Web10 de out. de 2008 · HIF, mTOR and UPR signalling during hypoxia influence tumour metabolism, autophagy and ER homeostasis. Many current and experimental anticancer … Web18 de fev. de 2024 · Hypoxia is a hallmark of solid tumors and plays a critical role in different steps of tumor progression, including proliferation, survival, angiogenesis, metastasis, metabolic reprogramming, and stemness of cancer cells. Activation of the hypoxia-inducible factor (HIF) signaling plays a critical role in regulating hypoxic responses in tumors. As a … chyna from wwe
PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia
Web9 de ago. de 2024 · The Akt inhibitor, wortmannin, could also inhibit the expression of HIF-1α at the protein, but not the mRNA level . mTOR is a hypoxia/nutrient sensor and a target of Akt during cell cycle regulation, glycogen metabolism and protein synthesis upon phosphorylation of its two main targets, eukaryotic initiation factor 4E-binding protein-1 … WebThe effects and mechanisms of isoliquiritigenin loaded nanoliposomes regulated AMPK/mTOR mediated glycolysis in colorectal cancer. Gang Wang a Department of … Web15 de set. de 2009 · Here, we found that the inhibition of mTOR signaling up-regulated CD133 expression at both the mRNA and protein levels in a CD133-overexpressing … dfw small engine repair grapevine tx