Scyphostatin a
WebbScyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissima: taxonomy of the producing organism, fermentation, isolation, and physico … Webb4 okt. 2002 · To construct a new strategy for synthesis of cyclopentanoids, the transition metal-catalyzed coupling reaction of cis 4-cyclopentene-1,3-diol monoacetate 1 with hard nucleophiles, R(T)-m, was investigated (eq 1 in Chart 1). Although preliminary experiments using PhZnCl, PhSnMe(3), [Ph-B(Me)(OCH(Me)C …
Scyphostatin a
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WebbThe cyclohexenone segment 2 of scyphostatin (1), a potent inhibitor of neutral sphingomyelinase, was synthesized in an enantioselective manner starting from the bromo ether 5 and D-serinal derivative 3. The synthetic method features a coupling reaction of 5 with 3 to construct the asymmetric quaternary carbon center and a stereospecific … Webb31 maj 2002 · The highly efficient and stereocontrolled syntheses of sphingomyelin carbon analogues 1 and 2 were achieved by effectively utilizing Hofmann rearrangement of enantiomerically pure β-hydroxyamide 7, which was prepared by an asymmetric hydrogenation of α-acyl-γ-butyrolactone 9 and ring opening with NH3. Intermediary …
Webb6 dec. 2024 · 优先权要求. 本申请要求于2024年9月28日提交的美国临时申请no.62/564,820；于2024年3月10日提交的美国临时申请no.62/469,989的权益。 WebbScyphostatin, which specifically inhibited N-SMase but not acid SMase activity, prevented mechanoactivation of N-SMase as well as downstream tyrosine and mitogen-activated protein kinases.
WebbScyphostatin C29H43NO5 CID 11248738 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … Webbscyphostatin. (2E,4E,6E,12E)- (8R,10S,14R)-8,10,12,14-Tetramethyl-hexadeca-2,4,6,12-tetraenoic acid [ (S)-1-hydroxymethyl-2- ( (1S,2S,6S)-2-hydroxy-3-oxo-7-oxa-bicyclo …
Webb1 feb. 2006 · Scyphostatin, isolated from the culture broth of Trichopeziza mollissima SANK 13892 in 1997, is a powerful and specific inhibitor of neutral sphingomyelinase (N …
Webb9 aug. 2004 · Abstract. The five crucial steps in the first total synthesis of (+)-scyphostatin from D -arabinose involve (see picture): a) stereoselective aldol coupling to form a … christophorushaus wolfen nordWebb28 apr. 2005 · Diastereoselective oxidative dearomatization of benzopyran 5 to the corresponding p-quinol 9b allows a fast, efficient, and versatile entry to scyphostatin's … gfl trash joplin moWebb1 juni 2005 · To test whether TNF-a-induced VEGF expression by LLC cells is mediated by neutral sphingomyelinase, we used a novel and specific small-molecule inhibitor of the enzyme, the scyphostatin analogue... christophorus heimWebb15 mars 2004 · Scyphostatin 1 was first isolated in 1997 by Ogita et al. from the mycelial extract of the microorganism Dasyscyphus mollissimus SANK-13892, 1 and its structure assigned by spectroscopic and derivatisation methods. Degradation studies by Kogen et al. 2 established the absolute stereochemistry, and determined the 14 ′ R, 10 ′ S, 8 ′ R … gfl trash lebanonchristophorushilfeWebb9 okt. 2024 · A concise synthesis of two scyphostatin analogues is achieved from readily available ortho-substituted phenols. Key features include an asymmetric and biomimetic hydroxylative phenol dearomatization (HPD) reaction promoted by a chiral salen-type bis(λ5-iodane) reagent, followed by an in situ regio- and diastereocontrolled epoxidation. christophorus heim hamburgWebb5 okt. 2024 · The synthesis of two diastereoisomers of the epoxycyclohexenone core of scyphostatin, a naturally occurring sphingomyelinase inhibitor, has been achieved via a … christophorushaus wolfen-nord